DNA damage theory

Alexander[51] was the first to propose that DNA damage is the primary cause of aging. Early experimental evidence supporting this idea was reviewed by Gensler and Bernstein.[52] By the early 1990s experimental support for this proposal was substantial, and further indicated that DNA damage due to reactive oxygen species was a major source of the DNA damages causing aging.[53][54][55][56][57] The current state of evidence bearing on this theory is reviewed in DNA damage theory of aging and by Bernstein et al.[5

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